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โ™ก Healthy lifestyle habits can help you to reach your blood glucose and blood pressure goals.
Following the steps below will also help to keep your kidneys healthy:

National Diabetes Month


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Evidence of a substantial heritability of diabetic kidney disease (DKD) exists but the genetic background is poorly understood.
Diabetes and kidneys
New data confirm that renal complications in type 1 diabetes mellitus (T1DM) areย highly heritable and provide insights into the biological mechanisms of DKD.basics diabetic nephropaty
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To comprehensively study the geneticย architecture of DKD in T1DM, Niina Sandholm and colleagues โ€” on behalf of the SUMMIT consortium โ€” performed a meta-analysis of genome-wide association studies, which included data from 12,540ย individuals. They also used whole-exome sequencing to investigate the effects of low-frequency and rare genetic variants in 997 patients with T1DM.
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โ€œWe found strong heritability estimates for DKD; additive genetic factors were estimated to explain 35% of the phenotypic variance and even higher heritability estimates wereย obtained for more extreme phenotypic definitions,โ€ says Sandholm. The analyses did not, however, identify novel susceptibility loci with robust evidence or confirm many previously published associations. The findings suggest that there are no low-frequency variants with a major effect on DKD risk.
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Using data from their meta-analysis, the researchers show thabasics diabetic nephropatyt sets of alleles thatย increase body mass index and genetic risk scores for type 2 diabetes are associated with an increased risk of DKD, whereas smoking cessation might have a protective effect.
In addition, they identified potential roles of ascorbate and aldarate metabolism andย pentose and glucuronate interconversion pathways in the pathogenesis of DKD.
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The researchers are now performing aย meta-analysis of data from nearly 18,000 patients with T1DM in the JDRF-DNCRI consortium to identify common and low-frequency genetic variation. They hope thatย thisanalysis will identify novel susceptibility lociย for DKD and provide biological information inย relation to other traits and diseases.
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ORIGINAL ARTICLEย Sandholm, N. et๎ผal. The geneticlandscape of renal complications in type 1 diabetes. J. Am. Soc. Nephrol.http://dx.doi.org/10.1681/ASN.2016020231(2016)
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