Polycystic kidney disease (PKD) is the most common genetic cause of kidney disease. This condition causes numerous fluid-filled cysts to grow in the kidneys, which can reduce kidney function and lead to kidney failure. We treat patients with autosomal dominant polycystic kidney disease (ADPKD).
Some people with PKD have few or no symptoms. For others, symptoms may include high blood pressure, blood in the urine, back pain or abdominal pain, urinary tract infection, or kidney stones.
Approximately 50% of patients reach end-stage kidney disease (ESKD) by age 50. There is no cure for ADPKD, but treatment may reduce symptoms and the chance of kidneys progressing to ESKD.
Treatment for hypertension (high blood pressure) is critical. Treatment also includes careful monitoring of the size of cysts that may convert into tumors. There is a 50% chance that the disease will be passed on to a patient’s children, and the children should be monitored for the disease once they reach age 30. PKD patients generally are very good candidates for a kidney transplant. For information about PKD clinical trials in the US, visit the PKD Cure site.